Background: Occupational hazards are one of the most important issues in developing countries. Meanwhile, hospitals are the most risky health provision centers, and nursing is one of the stressful jobs. Therefore, the present study aimed to study occupational hazards and their influential factors among nurses. Methods: This cross-sectional study was carried out in Sirjan and Baft hospitals in 2011. Two hundred nurses were included in this study using stratified random sampling. A questionnaire was used for data collection. Data analysis was conducted through SPSS 19 software and using chi-square test, Fisher’s Exact test and descriptive statistics. Results: The frequency of awareness and observing safety measures were respectively 98.5% and 86.0%. The Staff perception of safety was 99.5%. The rates of incurred physical and mental injuries to nurses were respectively 95.0% and 88.6%. The rate of physical invasion to the personnel was zero. There was a significant relationship between somatic injuries and variables of gender, education, working years and hospital. Also, a significant relationship was observed between the rate of awareness and type of employment. The awareness of nurses in emergency wards was less than others and the most mental injuries were seen among nurses working in CCU (100%) and emergency wards (94.1%). Conclusion: The results of the present study indicate psychosomatic injuries in a high number of the personnel. Therefore, it is recommended to spend a proper budget to provide the required equipment, in order to decrease occupational hazards to nurses.